COMMON FOUNDER EFFECTS OF HEREDITARY HEMOCHROMATOSIS, WILSON´S DISEASE, THE LONG QT SYNDROME AND AUTOSOMAL RECESSIVE DEAFNESS CAUSED BY TWO NOVEL MUTATIONS IN THE WHRN AND TMC1 GENES

Abstract Background Genealogy and molecular genetic studies of a Swedish river valley population resulted in a large pedigree, showing that the hereditary hemochromatosis (HH) HFE/p.C282Y mutation is inherited with other recessive disorders such as Wilson´s disease (WND), a rare recessive disorder of copper overload.The population also contain ind

Objective To examine the contribution of the active job openings-to-applicants ratio, a macroeconomic indicator, to the number of ambulance dispatches.Design Longitudinal ecological study.Setting Japan, between January 2003 and December 2021.Participants All ambulance dispatches.Primary and secondary outcome measures The contribution of the active

The detection and traceability research of massive log information has always been a focal read more point in Advanced Persistent Threats (APT) studies.Causality relationship technology analyzes attack paths and simplifies graph scale by mapping attack behaviors, but rule-based detection methods often introduce numerous false alarms.To address this